Associations of IL17A G-197A single nucleotide polymorphism with immunological parameters and structural changes of the brain in schizophrenia

Schizophrenia is a chronic mental disorder that caused by complex palette of genetic, epigenetic and environmental factors. Some the important components its pathogenesis are systemic inflammation dysfunction immunity, which lead to neuroinflammation, contributing development structural brain changes. Earlier we have shown increase in interleukin-17A levels associated with morphometric changes immune dysregulation schizophrenia. IL17A G-197A (rs2275913) genetic polymorphism involved determining secretion. The goal this work was investigate associations between rs2275913 polymorphism, disorders neurovisualization findings schizophrenia provide new insights into immunopathogenesis disease. 60 patients aged 18 42 years diagnosed were enrolled. 85 healthy volunteers included control group. Multiplex assay used determine cytokine chemokine serum levels. Rs2275913 assessed polymerase chain reaction electrophoretic detection amplification products. A number relationships parameters revealed. Carriers G allele showed significant IFNY, key Th1-link adaptive IL-8, an inflammatory chemokine. Also, increased CXCL16 observed carrying allele. activates secretion other proinflammatory chemokines activation Th1 immunity. Associations heterozygous GA genotype reduced cortical thickness areas frontal cortex found. Changes some these areas, including middle gyrus orbitofrontal cortex, can be relevant results highlight importance immunogenetic factors indicate requires further studies as potential biomarker